Dr. Jay Khorsandi, DDS is a dentist with more than 25 years of clinical practice, a sleep and airway educator, and the host of the Best Night Ever podcast. He is the medical reviewer for the content published on Sleep Biohacker.
Clinical background
Dr. Khorsandi earned his Doctor of Dental Surgery and has spent his career in private practice, with a clinical focus that moved steadily toward the airway. What began as routine dentistry became something else once he started noticing the pattern that most dentists see and few act on: worn teeth, scalloped tongues, tight jaws, and patients who were exhausted no matter how long they slept.
That pattern is the thread running through his work. The mouth is the front door to the airway, and dentists see it more often than anyone else in medicine. A dentist who knows what to look for is frequently the first person in a position to spot sleep disordered breathing, often years before it is formally diagnosed.
His areas of clinical focus include snoring and obstructive sleep apnea, oral appliance therapy, the relationship between bite alignment and airway volume, bruxism as an airway signal rather than a stress habit, and the role of tongue posture and myofunctional therapy.
Best Night Ever
Dr. Khorsandi hosts Best Night Ever, a podcast on sleep, recovery, and human performance. Guests have included Dave Asprey, Jim Kwik, and Shaquille O'Neal, alongside clinicians and researchers working in sleep medicine, dentistry, and longevity.
The show exists because the useful information about sleep is scattered across specialties that rarely talk to each other. Dentistry, sleep medicine, ENT, and circadian biology each hold part of the picture. The conversations are an attempt to put the pieces in one place, in language a non specialist can act on.
Media
Dr. Khorsandi has appeared on KTLA and FOX discussing sleep, oral health, and the connection between the two.
Editorial approach
Health content carries a duty of care, and that duty is easy to fail quietly. Articles on Sleep Biohacker are reviewed against these standards:
Claims are linked to their sources. If a statement rests on research, the research is cited and linked so you can read it yourself. If a specific study cannot be located, the claim does not run.
Uncertainty is stated, not smoothed over. Where the evidence is mixed, thin, or points somewhere inconvenient, the article says so. A supplement with promising mechanism and no human trials is described that way.
Effect sizes are described honestly. "Statistically significant" and "will change your life" are not the same claim, and the difference matters to anyone deciding whether something is worth their money.
Nothing here replaces clinical care. Persistent insomnia, loud snoring, witnessed pauses in breathing, or daytime sleepiness that does not resolve are reasons to see a clinician, not reasons to buy a supplement.
Where an article was drafted by a staff writer, Dr. Khorsandi reviews it for clinical accuracy before publication, and the byline reflects both roles.
Other work
Dr. Khorsandi is the founder of PRLY, an oral care company focused on the intersection of dental health and longevity science.
Contact
For media requests, speaking, or professional enquiries, reach the team at info@sleepbiohacker.com.